BCHE 4520/6520 - Design of Biochemical Separations Processes

Fall Semester 2022




Course Instructor

Dr. Mark A. Eiteman
021 Riverbend South

Office Hours

1) You may attend Zhelp sessions (i.e., "Zoom help"). That is, students may voluntarily log into a supplied Zoom Meeting ID, and seek guidance from me. These Zhelp sessions will be:

There may be times I need to modify these times due to personal conflicts, etc.

2) You may email me. This actually works well, just provide me with sufficient detail to allow me to understand your question (e.g., scan your attempts at a homework solution).

Course Description

Unit operations used for biological processing including filtration, centrifugation, cell disruption, isolation, purification, and polishing.

Meeting Time

8:00 - 8:50 MWF
Driftmier 1460

Calendar (Fall 2022)

Wednesday, Aug 17First Day of Classes
Monday, Sep 5No Class - Labor Day Holiday
Friday, Oct 28No Class - Fall Break
Nov 23 - Nov 25No Class - Thanksgiving Holiday (a)
Tuesday, Dec 6Last Day of Classes (b)
Friday, Dec 9, 8:00 - 11:00Final "Exam"
Final Exam Conflicts Procedure for Exam Conflicts

(a) We WILL have class on Monday, November 21.
(b) Tuesday, Dec 6 operates on a Friday schedule.


BCHE 3520 - Mass Transport and Rate Phenomena

Prerequisites by Topic

Differential Equations
Computer Programming
Stoichiometry and Fundamental Chemical Terms and Units
Chemical Equilibrium

Courses that Require this Course as a Prerequisite


Required Texts

  • Harrison, Todd, Rudge, Petrides, Bioseparations Science and Engineering, Oxford University Press
    First edition, 2003, ISBN 0-19-512340-9
    Second edition, 2015, ISBN 0-19-539181-0
  • Unbound Course Packet from University Bookstore. This is a collection of slides you will see this semester.

    Reference Texts

    Geankoplis, Transport Processes and Unit Operations, 3rd. ed., 1993, Prentice-Hall
    ISBN 0-13-930439-8
    Belter, Cussler, Hu, Bioseparations: Downstream Processing for Biotechnology, 1988, John Wiley and Sons
    ISBN 0-471-84737-2
    Dechow, Separation and Purification Techniques in Biotechnology, 1989, Noyes Publications
    ISBN 0-8155-1197-3
    Schweitzer, Handbook of Separation Techniques for Chemical Engineers, 2nd ed., 1988, McGraw-Hill
    ISBN 0-07-055808-6
    Ladisch, Bioseparations Engineering; Principles, Practice, and Economics, 2001, John Wiley and Sons
    ISBN 0-471-24476-7
    Svarovsky, Solid-Liquid Separation, 3rd. ed., 1990, Butterworth-Heinemann
    ISBN 0-7506-036-6

    Grading Policy:
    Design Project * *
    Term Paper/Presentation ("Final")13.0%13.0%
    Literature Reviews (3) 0% 7.6%
    Attendance and Participation 7.6% 7.6%
    * Design Project is not mandatory. If a student elects to complete this individual project, the average score weighted by 0.75 of this project and the lowest test score (0.25) will replace the lowest test score. For example, if the student's lowest test score is 52%, and the score earned on this project is 95%, then the score of (0.75*95+0.25*52) = 84.25% will replace 52% as that test score. If the score earned on this project is 62%, then the score of (0.75*62+0.25*52) = 59.5% will replace 52% as that test score. If the score on this project, when considered for the calculation, results in a decreased lowest test score, then no change will be made.


    Analysis of Activity and Purity
    Lysis and Flocculation

    Course Student Outcomes

    1) An ability to identify, formulate, and solve complex engineering problems by applying principles of engineering, sciences, and mathematicsextensive coverage
    2) an ability to apply engineering design to produce solutions that meet specified needs with consideration of public health, safety, and welfare, as well as global, cultural, social, environmental, and economic factors - moderate coverage
    3) an ability to communicate effectively with a range of audiences - moderate coverage
    4) an ability to recognize ethical and professional responsibilities in engineering situations and make informed judgments, which must consider the impact of engineering solutions in global, economic, environmental, and societal contexts - moderate coverage
    5) an ability to function effectively on a team whose members together provide leadership, create a collaborative and inclusive environment, establish goals, plan tasks, and meet objectives - some coverage
    6) an ability to develop and conduct appropriate experimentation, analyze and interpret data, and use engineering judgment to draw conclusions - some coverage
    7) an ability to acquire and apply new knowledge as needed, using appropriate learning strategies. - some coverage


    There will be four in-class tests during the semester. For individual students, the three highest test scores will each have a value towards the course grade of 19.6% (17.4% for grads), and the lowest score will have a value towards the course grade of 9.8% (8.7% for grads). Tests will be announced at least one week before the date.


    You must turn in paper solutions to homework (not scanned, digital) by the beginning of class on the assigned due date. I will not accept late homework. Please indicate the source for all information used in the solution of your homework problems. You are encouraged to discuss problems with other students, however, duplicating another student's work will be considered plagiarism, and this practice is unacceptable (see Academic Honesty below). If you receive considerable aid on a particular problem you are to indicate so on your homework. Neatness and clarity will be important factors in assigning homework grades. There will be no unannounced quizzes. For current information on homework, please see the BCHE 4520/6520 homework web page.

    Term Paper

    The term paper "Final" and literature reviews must be typewritten and double spaced. References should be list in alphabetical order beginning on a separate page at the end of the paper. References from web sites must be from federal government sites or from academic institutions (e.g., .gov or .edu). For advice on the preparation of a written report see Preparation of written reports. More details will be provided at the BCHE 4520/6520 homework web page.


    There are 45 class meetings (which includes the four in-class tests). A student must attend 42 class meetings to receive a full "attendance" score. Each absence beyond this number will result in a deduction of 7% in attendance score (about 1/2 letter score per absence, i.e., 41 days of attendance = A, 40 days of attendance = B+, etc.).

    A student may also receive credit for significant and meaningful participation in discussion both in class and out of class (zHelp sessions). This credit is used as "bonus" to increase attendance score. The maximum "bonus" is 15%.

    Reasonable accommodations/exceptions will be made for students facing unusual circumstances or hardships (see COVID-19 section below). Please communicate with your instructor at eiteman@engr.uga.edu.

    The maximum attendance score is 100% regardless of attendance or participation.

    Academic Honesty

    All students are responsible for maintaining the highest standards of honesty and integrity in every phase of their academic careers. The penalties for academic dishonesty are severe and ignorance is not an acceptable defense. The UGA Student Honor Code states: "I will be academically honest in all of my academic work and will not tolerate academic dishonesty of others." A Culture of Honesty, the University's policy and procedures for handling cases of suspected dishonesty, can be found at Academic Honesty Policy.

    Mental Health and Wellness Resources

    If you or someone you know needs assistance, you are encouraged to contact Student Care and Outreach in the Division of Student Affairs at 706-542-7774 or visit sco.uga.edu. They will help you navigate any difficult circumstances you may be facing by connecting you with the appropriate resources or services. UGA has several resources for a student seeking mental health services (www.uhs.uga.edu/bewelluga/bewelluga) or crisis support (www.uhs.uga.edu/info/emergencies). If you need help managing stress anxiety, relationships, etc., please visit BeWellUGA (www.uhs.uga.edu/bewelluga/bewelluga) for a list of FREE workshops, classes, mentoring, and health coaching led by licensed clinicians and health educators in the University Health Center. Additional resources can be accessed through the UGA App.

    Communication Skills

    In accordance with departmental policy concerning communication skills, fifty percent of the grade on all written assignments and oral presentations will be based on quality of communication. Spelling, grammar, punctuation, and clarity of writing are evidence of written communication quality. Enunciation, voice projection, clarity and logical order of the presentation and effective use of visual aids are evidence of oral communication quality.

    Engineering Professionalism

    The engineering profession is governed by a code of ethics that have developed alongside the rigors of the practice and its many contributions to society. Engineering students at the University of Georgia are responsible for maintaining the highest standards of professionalism and professional practice. Engineering faculty at the University of Georgia expect students to act in a professional manner at all times.


    As of the beginning of the semester, The University of Georgia does not require faculty, students and visitors to wear a face mask while inside campus facilities. However, students are strongly encouraged to continue wearing face coverings and distancing from others when possible.

    Students are strongly encouraged to obtain vaccination and booster injections for COVID-19. You may schedule an appointment for a vaccination through the UGA Vaccine Portal.

    Students who learn they have been directly exposed to COVID-19 but are not showing symptoms should self-quarantine consistent with Department of Public Health (DPH) and Centers for Disease Control and Prevention (CDC) guidelines. Please correspond with your instructor via email at eiteman@engr.uga.edu, with a copy to Student Care & Outreach, to coordinate continuing your coursework while self-quarantined. If you develop symptoms, you should contact the University Health Center to make an appointment to be tested. You should continue to monitor your symptoms daily on DawgCheck.

    Students who are eligible for COVID-19 related ADA accommodations (e.g., individuals with underlying medical conditions that put them at higher risk from COVID-19) should refer to the Disability Resource Center.

    Students who need other COVID-19 related accommodations (e.g., they live with at-risk individuals) should refer to Student Care and Outreach.

    Students must recognize that the circumstances and guidance related to the COVID-19 pandemic remain fluid, and that the course policies may change quickly from policies described on this website. Students should be aware of current Department of Health and CDC guidance on issues related to COVID-19.


    A student may be withdrawn from this course by the instructor without notification to the student for failure to complete necessary prerequisites. A student may also be withdrawn from this course by the instructor after one warning for disruption of class. Ringing of a cell phone during the lecture constitutes a "disruption of class."

    The instructor will provide students with an opportunity to complete academic responsibilities resulting from absences due to (for example) 1) observation of religious holidays, 2) significant illness, 3) death in family and 4) emergencies. The instructor requires reasonable (~ one week) written notice of absences when possible. Please communicate promptly with instructor such absences, including date and reason for absence, and proposed alternative for academic responsibilities.