BCHE 4520/6520 - Design of Biochemical Separations Processes

Fall Semester 2017




Course Instructor

Dr. Mark A. Eiteman
408 Driftmier

Office Hours

By chance or by appointment

Course Description

Unit operations used for biological processing including filtration, centrifugation, cell disruption, isolation, purification, and polishing.

Meeting Time

8:00 - 8:50 MWF
Driftmier 305

Calendar (Fall 2017)

Monday, Aug 14First Day of Classes
Monday, Sep 4Labor Day Holiday
Friday, Oct 27Fall Break
Nov 20 - Nov 24Thanksgiving Holiday (week)
Tuesday, Dec 5Last Day of Classes*
Monday, Dec 11, 8:00 - 11:00Final "Exam"
Final Exam Conflicts Procedure for Exam Conflicts
* NOTE: Tuesday, Dec 5 will operate on a Friday Schedule!


ENGR 3520 - Mass Transport and Rate Phenomena

Prerequisites by Topic

Differential Equations
Computer Programming
Stoichiometry and Fundamental Chemical Terms and Units
Chemical Equilibrium

Courses that Require this Course as a Prerequisite


Required Texts

  • Harrison, Todd, Rudge, Petrides, Bioseparations Science and Engineering, 2003, Oxford University Press
    ISBN 0-19-512340-9
  • Unbound Course Packet from University Bookstore. This is a collection of slides you will see this semester.

    Reference Texts

    Geankoplis, Transport Processes and Unit Operations, 3rd. ed., 1993, Prentice-Hall
    ISBN 0-13-930439-8
    Belter, Cussler, Hu, Bioseparations: Downstream Processing for Biotechnology, 1988, John Wiley and Sons
    ISBN 0-471-84737-2
    Dechow, Separation and Purification Techniques in Biotechnology, 1989, Noyes Publications
    ISBN 0-8155-1197-3
    Schweitzer, Handbook of Separation Techniques for Chemical Engineers, 2nd ed., 1988, McGraw-Hill
    ISBN 0-07-055808-6
    Ladisch, Bioseparations Engineering; Principles, Practice, and Economics, 2001, John Wiley and Sons
    ISBN 0-471-24476-7
    Svarovsky, Solid-Liquid Separation, 3rd. ed., 1990, Butterworth-Heinemann
    ISBN 0-7506-036-6

    Grading Policy:

    Test #1 (Errors/Disruption)18%16%
    Test #2 (Filtration)18%16%
    Test #3 (Sedimentation/Extraction)18%16%
    Test #4 (Adsorption/Precipitation/Crystallization)18%16%
    Design Project8%8%
    Term Paper/Presentation ("Final")12%12%
    Literature Reviews (3)0% 7%
    Attendance and Participation 7% 7%
    The lowest scored test (for each student) will count for half the percentage(9%)(8%)


    Analysis of Activity and Purity
    Lysis and Flocculation

    Course Program Outcomes

    a) an ability to apply knowledge of mathematics, science and engineering - extensive coverage
    b) an ability to design and conduct experiments, as well as to analyze and interpret data - no coverage
    c) an ability to design a system, component, or process to meet desired needs - moderate coverage
    d) an ability to function on multi-disciplinary teams - some coverage
    e) an ability to identify, formulate, and solve engineering problems - some coverage
    f) an understanding of professional and ethical responsibility - some coverage
    g) an ability to communicate effectively - moderate coverage
    h) an understanding of the impact of engineering solutions in a global and societal context - some coverage
    i) a recognition of the need for and an ability to engage in life-long learning - no coverage
    j) a knowledge of contemporary issues - some coverage
    k) an ability to use techniques, skills and modern engineering tools necessary for engineering practice - moderate coverage


    Homework will be discussed at the beginning of each period, then collected. Please indicate the source for all information used in the solution of your homework problems. You are encouraged to discuss problems with other students, however, duplicating another student's work will be considered plagiarism, and this practice is unacceptable (see Academic Honesty below). If you receive considerable aid on a particular problem you are to indicate so on your homework. Neatness and clarity will be important factors in assigning homework grades. Excused late homework will only be accepted under extreme circumstances (e.g., personal crises). Unexcused homework one class period late will receive 50% of maximum possible credit, beyond one class unexcused late homework will not be given credit. There will be no unannounced quizzes. For current information on homework, please see the BCHE 4520/6520 homework web page.


    You may bring pencils, paper, erasers, and calculators to tests. You will be supplied with any equations or other information needed. There will be absolutely no sharing of calculators nor talking during test periods. Testing dates will not be altered, and "make-up" tests will only be given under extreme circumstances.

    Term Paper

    The term papers and literature reviews must be typewritten and double spaced. References should be list in alphabetical order beginning on a separate page at the end of the paper. References from web sites must be from federal government sites or from academic institutions (e.g., .gov or .edu). For advice on the preparation of a written report see Preparation of written reports.

    Academic Honesty

    All students are responsible for maintaining the highest standards of honesty and integrity in every phase of their academic careers. The penalties for academic dishonesty are severe and ignorance is not an acceptable defense. The document for academic dishonesty may be found at the web site for The University of Georgia Office of the Senior Vice President for Academic Affairs and Provost: Academic Honesty

    Communication Skills

    In accordance with departmental policy concerning communication skills, fifty percent of the grade on all written assignments and oral presentations will be based on quality of communication. Spelling, grammar, punctuation, and clarity of writing are evidence of written communication quality. Enunciation, voice projection, clarity and logical order of the presentation and effective use of visual aids are evidence of oral communication quality.

    Engineering Professionalism

    The engineering profession is governed by a code of ethics that have developed alongside the rigors of the practice and its many contributions to society. Engineering students at the University of Georgia are responsible for maintaining the highest standards of professionalism and professional practice. Engineering faculty at the University of Georgia expect students to act in a professional manner at all times.


    A student may be withdrawn from this course by the instructor without notification to the student for excessive absences or for failure to complete necessary prerequisites. For this course, "excessive absences" is defined as absence from three contiguous class meetings. A student may also be withdrawn from this course by the instructor after one warning for disruption of class. Ringing of a cell phone during the lecture constitutes a "disruption of class."

    The instructor will provide students with an opportunity to complete academic responsibilities resulting from absences due to (for example) 1) observation of religious holidays, 2) significant illness, 3) death in family and 4) emergencies. The instructor requires reasonable written notice of absences (one week, when possible). Please communicate promptly with instructor such absences, including date and reason for absence, and proposed alternative for academic responsibilities.